Discover synergistic drugs for gene cell lines and analyse genes signaling network interaction with GBCN
Complex signaling pathways/networks are believed to be responsible for drug resistance in cancer therapy. And there are 2 challenges always being an open problem for effective drug combination prediction. First, the complex and biological meaningful gene regulatory relationships were not incorporated, and thus were not interpretable. Second, no model was designed to investigate complex mechanism of synergy (MoS). In this study, we proposed a novel computational model, DeepSignalingFlow, to investigate these 2 challenges.
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